|
Mathias Uhlen
Professor
KTH Biotechnology
AlbaNova University Center
Royal Institute of Technology (KTH)
106 91 Stockholm, Sweden
Email:
Direct phone: +46 (0) 8 5537 8325
Secr: +46 (0) 8 5537 8403
Fax: +46 8 5537 8482
Bibliography
10 selected innovations |
Short Biography |
Mathias Uhlen is Professor of Microbiology at
the Royal Institute of Technology (KTH), Stockholm, Sweden.
Dr Uhlen is member of the Royal Swedish Academy of Engineering
Science (IVA), the Royal Swedish Academy of Science (KVA), the
European Molecular Biology Organization (EMBO) and member of
the Human Proteome Organization (HUPO) council. He was Vice-President
of the Royal Institute of Technology (KTH), responsible for
external relations, from 1999 to 2001. He was the chairman of
the Swedish Biochemical and Molecular Biology Society (SFMB)
from 1994 to 1999. Dr Uhlen has more than 300 publications in
bioscience with the focus on the development and use of affinity
reagents in biotechnology and biomedicine. |
| In the early eighties, Dr Uhlen cloned and characterized
staphylococcal protein A, which is now used extensively for purification
of antibodies both in diagnostics and therapy. He also showed
in 1983 that protein A could be used as an affinity tag for purification
of other proteins. The use of affinity tags for purification of
recombinant proteins are now widely used in bioscience. In the
late eighties, Uhlen published the use of magnetic micro spheres
with streptavidin for automated solid phase applications. Such
laboratory systems based on streptavidin beads are at present
frequently used both in research and diagnostics. In the 90:ies,
his group described a new principle for affinity reagents, called
Affibodies, and showed their use as research tool and recently
as potential cancer therapeutics. Uhlen and colleagues also developed
a new strategy for DNA analysis called Pyrosequencing, a method
that has recently been further developed by a US company into
a highly parallelized sequencing instrument. |
| Dr Uhlen is currently working on the Human Protein
Resource Project (HPR), with the aim to systematically map the
human proteome. At present, the Human Protein Atlas portal (www.proteinatlas.org)
contains more than 7 million high-resolution images representing
6,800 human proteins. |
| He has founded several companies, including Pyrosequencing
AB (now Biotage AB), Affibody AB, SweTree Technologies AB, Magnetic
Biosolutions AB (now Nordiag AS), Atlas Antibodies AB and Creative
Peptides AB. He has received numerous awards, including The Svedberg
prize in 1992, the Göran Gustavsson prize in 1993, the gold
medal of the Royal Swedish Academy of Engineering Sciences in
2004, the Most Noble Order of the Seraphim - the Order of His
Majesty the King in 2004, the Jerker Porath award in 2005, the
Akzo Noble Award in 2005, the HUPO Distinguished Award and KTH
Great Prize both in 2006 and the Scheele prize in 2007. |
|
