Principal Investigator (PI): Associate Professor, Jacob Odeberg, MD PhD

Group members:
Dr Sarah-Jane Reilly, PhD (post doc)
Dr Maria Jesus Iglesias, PhD (post doc)
Dr Maria Bruzelius, MD (PhD student)

Affiliations:

1)	Department of Proteomics, School of Biotechnology (KTH) and Science for Life Laboratory (Stockholm).
2)	Cardiovascular Genetics and Genomics, Centre for Molecular Medicine, Karolinska Institutet.

Description of research:

Clinically applied proteomics for identification of disease-specific plasma biomarkers
Together with the Biobank Profiling group, antibody based proteomics is applied to the identification of novel plasma biomarkers for different disease entities in clinical sample cohorts. The focus is on cardiovascular and thromboembolic disorders.

Genetic variation affecting protein expression and the link to complex disease.
A combined bioinformatic and molecular genetic approach is applied to identify and characterize the roles of individual genetic variations in gene regulatory regions on a molecular level. The work includes identification of candidate genes and gene variations primarily influencing protein expression, by combining gene expression analysis, ChIP-seq analysis and genotype data from Genome Wide Association Studies (GWAS) to yield novel biomarkers for disease risk and targets for prevention and treatment. The focus is on inflammation and cardiovascular and thromboembolic disorders