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Research Groups

Eleven principal investigators at the School of Biotechnology, KTH, are actively involved in the ProNova Centre:

Prof. Mathias Uhlén (Proteomics, automation and bioinformatics)

Mathias Uhlen is the Programme Director of the ProNova VINN Excellence Centre for Protein Technology. After PhD studies at the Royal Institute of Technology and PostDoc experience at the EMBL (Heidelberg, Germany), he became full professor at KTH in 1988. He has over 300 peer-reviewed publications in the field of biotechnology with a focus on the use of affinity-reagens for life science research. Scientific achievements include the development of the affinity tag concept (1983), protein A (1984), streptavidin magnetic beads (1988), affibodies (1996), pyrosequencing (1998), the human protein atlas (2005) and bacterial surface display for epitope mapping (2008). Dr Uhlen leads the Protein Atlas effort with two main sites in Sweden and three sites in Asia (Korea, China and India) and within the ProNova Centre, Dr Uhlen is a project leader in Program Area 2 “Array technologies”, working on the development of improved strategies for epitope mapping of antibodies.

 

Prof. Helene Andersson Svahn (Microfluidics and bioimaging)

Professor Helene Andersson Svahn is heading the Nanobiotechnology department at the Royal Institute of Technology in Sweden. Dr. Andersson Svahn received her Ph. D. in Electrical Engineering at the Royal Institute of Technology in 2001 and holds a M. Sc. in Molecular Biotechnology from Uppsala University. Her main research focus is micro- and nano-fluidic devices for cell and protein analysis. Dr. Andersson Svahn has published numerous journal articles in the Lab-on-a-chip field and has several patents. In 2003 Dr. Andersson Svahn was selected as member of the ‘TR100: Innovators under 35 who will create the future’ at MIT in USA. In 2006 Dr Andersson Svahn was awarded a prestigious research fellowship from the Royal Swedish Academy of Sciences.

In 2002-2005 Dr Andersson Svahn was Marketing Director at Silex Microsystems which develops and manufactures microchips for Telecom and Life Science Industry. In 2005-2008 she was professor in Applied BIOMEMS at MESA+ Research Institute in Holland. Currently she is CEO of the startup company Picovitro AB (part time) and scientific advisor for Silex Microsystems.

Prof. Helene Andersson Svahn is heading the Program Area ‘Microfluidics’ in the ProNova Center involving two main focus areas 1) droplet microfluidics and 2) flow microarray platforms for on-site diagnosis.

 

Prof. Amelie Eriksson Karlström (Protein chemistry and peptide synthesis)

Amelie Eriksson Karlström has a PhD from Stockholm University and two years of PostDoc experience at the Scripps Research Institute in La Jolla, California. She has been at KTH Biotechnology since 1999, where she is currently Professor of Molecular Biotechnology. Her research group is focused on chemical engineering of proteins using a combination of peptide synthesis and recombinant technologies to produce site-specifically modified proteins for different diagnostic and medical applications. In the ProNova Centre, Amelie Eriksson Karlström is a project leader in Program Area 1 “Affinity Tools and Protein Engineering”, working on the development of improved strategies for antibody labeling.

 

Prof. Per-Åke Nygren (Protein engineering and combinatorial methods)

Per-Åke Nygren is Director of the ProNova Centre and is currently a project leader in Program Area 1 "Affinity Tools and Protein Engineering". His research is focused on combinatorial protein engineering.

 

Assoc. Prof. Jochen Schwenk (Suspension arrays and plasma profiling)

Dr. Jochen M. Schwenk is principal investigator for the plasma profiling group within the Human Protein Atlas project. He began his scientific career with the development of protein microarrays receiving PhD in Biochemistry in 2005 from the University of Tuebingen in Germany. He then joined the Human Protein Atlas project with funding from the Wallenberg foundation and became an external postdoc for Roche in 2007. Dr. Schwenk was nominated as “KTH star of 2009” for the WCN symposium on Frontiers in The New Biology. In the ProNova Centre, Jochen Schwenk is a project leader in Programme Area 2 “Array Technologies”, working on high-throughput analysis of serum and plasma using suspension bead arrays.

 

Prof. Peter Nilsson (Microarrays and automation)

Peter Nilsson is Professor of Proteomics at the School of Biotechnology at KTH Royal Institute of Technology. He took his Ph.D. degree in Biotechnology at KTH in 1998. He has been the Head of the KTH Microarray Center between 1999 and 2008, with massive production and analysis of various types of DNA microarrays within the KTH Genome Center. He has since 2002 also been heading the protein array activities within the Human Protein Atlas. The main research focus is on the development and utilization of array-based technologies for validation of antibodies and for systematic antigen- and antibody-based plasma profiling, see the following link for a complete list of publications. He has been a Member of the HUPO since 2003.

PN is heading the Program area 2 “Array Technologies” and is also PI for one of the projects in this area.

 

Prof. Stefan Ståhl (Biotherapy and bacterial display)

Stefan Ståhl received his PhD in 1992, and has since then acted as research leader in Molecular Biotechnology at the Royal Institute of Technology (KTH), Stockholm, Sweden. He became professor 1999, and was in January 2005 appointed Dean for the School of Biotechnology, one of the ten schools of KTH. Stefan is cofounder of the biotech companies Creative Peptides AB (1996), Affibody AB (1998) and Visual Bioinformatics AB (1999). Between 2000 and 2002 he acted as CSO for Affibody AB, while the company grew from four to 65 employees, still retaining PhD students and research activity at KTH. Since 2003 he is back in the academic environment at KTH, but with strong links to industry. Stefan is the inventor of a number of patents, and has published more than 150 scientific papers in international peer-reviewed journals, supervised 17 PhD students to their dissertation and given more than 60 lectures as invited speaker at various international meetings and conferences. In the ProNova Centre, Stefan is the project leader in Program Area 1 “Affinity Tools and Protein Engineering”, working on the further development and implementation of a bacterial display platform.

 

Prof. Sophia Hober (Protein expression and engineering)

Sophia Hober is Professor of Molecular Biotechnology at KTH, Stockholm, Sweden. She is the Dean of Faculty of KTH since 2011. Sophia is cofounder of the biotech companies Affibody AB (1998) and Atlas Antibodies AB (2006). Dr. Hober has published more that 65 scientific papers and is also the inventor of a number of patents. The focus of her current research group is development of predictable and robust systems for protein purification and detection by protein design and various selection methodologies. Her key scientific achievements includes characterization of the folding pathway of IGF-1, design and development of gene fusion systems for selective ion-exchange purification and improvements of the alkaline tolerance of protein A and protein G for industrial purification of IgG/HSA. Dr Hober is a project leader in Program Area 1 “Affinity Tools and Protein Engineering”, working on the development of improved strategies for antibody labeling, where she also acts as project leader.

 

Assoc. Prof. Afshin Ahmadian (Microarrays and genetic analysis)

 

Assist. Prof. John Löfblom (protein engineering and combinatorial methods)

 

Dr. Johan Rockberg (flow cytometry and immunotechnology)

 

 

 

Last updated: October 4, 2013