Department of Biotechnology
Molecular Biotechnology
Research
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  Key scientific achievements
Research groups
Summary
Staphylococcal selection
Amyloid beta peptide
In vivo tumor targeting
Targeting of gene therapy vector
Tumor targeting
Affibody 3D-structure
Affibody binding proteins
Biosensor (DNA)
Surface display
In vivo stabilization


Year Research field Description Key reference
2008 Staphylococcal selection Proof of concept for staphylococcal selection from protein libraries Kronqvist et al Prot. Eng. Design Select. 21: 247-255 (2008)
2008 Amyloid beta peptide solution structure Affibody-mediated NMR structure determination of the Alzheimer amyloid beta peptide Hoyer et al Proc. Natl. Acad. Sci. USA 105: 5099-5104 (2008)
2007 Tumor targeting In vivo tumor targeting using high-affinity affibody ligand to EGFR. Friedman et al Prot. Eng. Design Select. 20: 189-199 (2007);
Friedman et al J. Mol. Biol. 376: 1388-1402 (2008)
2007 Targeting of gene therapy vector Affibody-mediated targeting of adenovirus gene therapy vector Magnusson et al Cancer Gene Therapy 14: 468-479 (2007)
2005 Tumor targeting HER2-specific affibody ligands enable targeting of xenografted tumors in mice Wikman et al (2004) Protein Eng. Des. Sel. 17:455-462
2003 Affibody 3D-structure First molecule 3D-structures (NMR and X-ray cryst.) of a selected affibody, together with the target protein Högbom, et al. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 3191-3196;
Wahlberg et al., (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 3185-3190.
1995 Affibody binding proteins Pioneering work on non-Ig binding proteins developed by combinatorial protein engineering
Nord et al (1997) Nature Biotechn 15: 772-777;
Nygren (2008) FEBS J. 275, 2668-2676.
1995 Biosensor analysis of DNA manipulations The first report on real-time biosensor analysis of DNA manipulations Nilsson et al (1995) Anal Biochem 224: 400-408
1992 Gram+ bacterial surface display The first report on the use of Gram positive bacteria for surface expression of recombinat proteins Hansson et al (1992) J. Bacteriol. 174: 4239-4245
1991 In vivo stabilization of recombinant proteins The half-life of recombinant proteins in circulation can be increased by fusion to an albumin-binding domain Nygren et al (1991) Vaccines 91: 363-368
Last updated: 2008-06-05