| Year |
Research
field |
Description |
Key reference |
| 2008 |
Staphylococcal selection |
Proof of concept for staphylococcal
selection from protein libraries |
Kronqvist et al Prot. Eng.
Design Select. 21: 247-255 (2008) |
| 2008 |
Amyloid beta peptide solution
structure |
Affibody-mediated NMR structure
determination of the Alzheimer amyloid beta peptide |
Hoyer et al Proc. Natl. Acad.
Sci. USA 105: 5099-5104 (2008) |
| 2007 |
Tumor targeting |
In vivo tumor targeting using
high-affinity affibody ligand to EGFR. |
Friedman et al Prot. Eng.
Design Select. 20: 189-199 (2007);
Friedman et al J. Mol. Biol. 376: 1388-1402 (2008) |
| 2007 |
Targeting of gene therapy vector |
Affibody-mediated targeting
of adenovirus gene therapy vector |
Magnusson et al Cancer Gene
Therapy 14: 468-479 (2007) |
| 2005 |
Tumor
targeting |
HER2-specific affibody ligands
enable targeting of xenografted tumors in mice |
Wikman et al (2004) Protein
Eng. Des. Sel. 17:455-462 |
| 2003 |
Affibody 3D-structure |
First molecule 3D-structures
(NMR and X-ray cryst.) of a selected affibody, together
with the target protein |
Högbom, et al. (2003) Proc.
Natl. Acad. Sci. U.S.A. 100, 3191-3196;
Wahlberg et al., (2003) Proc. Natl. Acad. Sci. U.S.A.
100, 3185-3190. |
| 1995 |
Affibody
binding proteins |
Pioneering work on non-Ig binding
proteins developed by combinatorial protein engineering
|
Nord et al (1997) Nature
Biotechn 15: 772-777;
Nygren (2008) FEBS J. 275, 2668-2676. |
| 1995 |
Biosensor
analysis of DNA manipulations |
The first report on real-time
biosensor analysis of DNA manipulations |
Nilsson et al (1995) Anal
Biochem 224: 400-408 |
| 1992 |
Gram+
bacterial surface display |
The first report on the use
of Gram positive bacteria for surface expression of recombinat
proteins |
Hansson et al (1992) J.
Bacteriol. 174: 4239-4245 |
| 1991 |
In
vivo stabilization of recombinant proteins |
The half-life of recombinant
proteins in circulation can be increased by fusion to an
albumin-binding domain |
Nygren et al (1991) Vaccines
91: 363-368 |
