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Christina Divne, universitetslektor
Short biography
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Associate Professor, Lecturer 50% KTH / 50% Karolinska Inst. (KI) |
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Associate Professor, Lecturer (Docent, universitetslektor) KTH |
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Associate Professor (Docent, forskare) KTH Biotechnology |
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Associate Professor (Docent, forskarassistent) KTH Biotechnology |
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Docent in Molecular Biology, Uppsala University |
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Assistant Professor (Forskarassistent), Uppsala University |
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Post-doctoral position, Uppsala University |
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PhD degree, Uppsala University |
Responsible for the course Structure Biology BB2160,
(BB2160 home page)
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Links to Divne biography | Divne publications | Sponsors |
KI MBB website |
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Group members |
Christina Divne, Principal Investigator KI / KTH
Tien-Chye Tan, postdoc KI
Rosaria Gandini, postdoc KI
Noor Hassan, PhD student KTH
Our research activities are currently located at KI MBB, Biophysics
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Research |
See these links to the research database at KTH:
Pyranose-oxidizing enzymes |
Cellobiose dehydrogenase |
Protein-based nano-system for drinking water treatment |
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Key Publications |
Tan, T.C., Haltrich, D. & Divne, C.
(2011). Regioselective control of beta-D-glucose oxidation by pyranose 2-oxidase is intimately
coupled to conformational degeneracy.
J. Mol. Biol. 409, 588-600.
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Tan, T.C., Pitsawong, W., Wongnate, T., Spadiut, O., Haltrich, D., Chaiyen, P. & Divne, C.
(2010). H-bonding and positive charge at the N5/O4 locus are critical for covalent
flavin attachment in Trametes pyranose 2-oxidase.
J. Mol. Biol. 402, 578-594.
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Spadiut, O., Tan, T.C., Pisanelli, I., Haltrich, D. & Divne, C.
(2010). Importance of the gating segment in the substrate-recognition loop
of pyranose 2-oxidase.
FEBS J. 277, 2892-2909.
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Gullfot, F., Tan, T.C., von Schantz, L., Nordberg Karlsson, E., Ohlin,
M., Brumer, H. & Divne, C. (2010). The crystal structure of
XG-34, an evolved xyloglucan-specific carbohydrate-binding module.
Proteins,
78, 785-789. |
Tan, T.C, Mijts, B.N., Swaminathan, K., Patel, B.K.C., & Divne,
C. (2008). Crystal structure of the polyextremophilic alpha-amylase
AmyB from Halothermothrix orenii: details of a productive
enzyme-substrate complex and an N domain with a role in binding raw
starch.
J.
Mol. Biol. 378, 850-868. |
Kujawa, M., Ebner H., Leitner C., Hallberg B.M., Prongjit, M.,
Sucharitakul, J., Ludwig R., Rudsander U., Peterbauer C., Chaiyen
P., Haltrich D. & Divne C. (2006). Structural basis for
substrate binding and regioselective oxidation of monosaccharides at
C3 by pyranose 2-oxidase.
J. Biol. Chem.
281, 35104-35115. |
Hallberg B.M., Leitner C., Haltrich D. & Divne C. (2004).
Crystal structure of the 270 kDa homotetrameric lignin-degrading
enzyme pyranose 2-oxidase.
J. Mol.
Biol. 342, 781-796. |
Hallberg, B.M., Henriksson, G., Pettersson, G., Vasella, A. &
Divne, C. (2003). Mechanism of the reductive half reaction in
cellobiose dehydrogenase.
J. Biol. Chem.
278, 7160-7166. |
Hallberg, B.M., Henriksson, G., Pettersson, G. & Divne, C.
(2002). Crystal structure of the flavoprotein domain of the extracellular
flavocytochrome cellobiose dehydrogenase.
J. Mol.
Biol. 315, 421-434. |
Hallberg, B.M., Bergfors, T., Bäckbro, K., Pettersson, G., Henriksson,
G. & Divne, C. (2000). A new scaffold for binding of haem in
the cytochrome domain of the extracellular flavocytochrome
cellobiose dehydrogenase.
Structure, 8, 79-88. |
Divne, C., Ståhlberg, J., Teeri, T.T. & Jones, T.A.
(1998). High-resolution crystal structures reveal how a cellulose chain is
bound in the 50Å long tunnel of cellobiohydrolase I from
Trichoderma reesei.
J. Mol. Biol
275, 309-325. |
Divne, C., Ståhlberg, J., Reinikainen, T., Ruohonen, L.,
Pettersson, G., Knowles, J.K.C., Teeri, T.T. & Jones, A. (1994). The
three-dimensional structure of the catalytic core of
cellobiohydrolase I from Trichoderma reesei.
Science, 265, 524-528. |
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